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Poster: elbow1126 Date: Aug 31, 2012 5:31am
Forum: GratefulDead Subject: Re: Best News In Years

I did a pubmed search and found they published this in the Journal of Medicinal Chemistry back in April. I can't access the journal from home but at least you can see the abstract here. This is a reputable journal but not where i would have expected such a potentially high impact finding. I think i have access at work so I will check it out then. The abstract does not mention anything about mechanism of action, which may explain why this is not in a high profile journal.

http://pubs.acs.org/doi/abs/10.1021/jm3001373

The abstract does point to the concern that was raised by Little Sense regarding mouse models. The mice they cured were infected with Plasmodium berghei. This species does not infect humans. Although they have shown activity against drug-resistant strains that do infect humans, that was done in a test tube.

Okay, i read the paper and the drug at 30 mg/kg will cure (no evidence of parasites after 30 days) after a single oral dose. As a reference, the old warhorse of malaria treatment, chloroquine will also cure these mice at dose of 30 mg/kg, but it takes four oral doses. The only concern that was raised was a potential for some cardiotoxicity although it seemed pretty mild. They do comment on the fact that they have no idea how the drug works.

So this looks like a small step. If it were a vaccine, as micah had originally suggested, then it would be a giant leap.

This post was modified by elbow1126 on 2012-08-31 12:31:26

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Poster: cosmicharIie Date: Aug 31, 2012 5:56am
Forum: GratefulDead Subject: Re: Best News In Years

eh...ya gotta die of something

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Poster: elbow1126 Date: Aug 31, 2012 5:58am
Forum: GratefulDead Subject: Re: Best News In Years

Well that has been one of the debates in the comments from the original article that micah posted. If you cure malaria in Africa, how are you going to feed everyone? I think you cross that bridge when you get there but you should strive to get there.